![]() Furthermore, the association between MOV10L1 gene polymorphisms and complete maturation arrest in men has been discussed. The biological characteristics of piRNA has been summarized, and emphasis was laid on the roles of MOV10L1 in the mediation of piRNA biogenesis and retrotransposons silencing by DNA methylation. This review addresses the advances on piRNAs and piRNA biogenesis-associated genes, with a particular focus on the Moloney leukemia virus 10-like 1 ( MOV10L1) gene, whose role in primary piRNA processing and in the ‘ping–pong’ cycle during secondary piRNA processing has been illustrated. In the past decade, significant progress has been achieved for piRNAs and their roles in male germ cells. Previous studies on the animal models harboring gene deletions have shown that the genes involved in piRNA biogenesis and their defective expression can result in the spermatogenic dysfunction. It is well known that piRNAs can maintain genome integrity via silencing retrotransposons. ![]() ![]() Piwi-interacting RNAs (piRNAs) are a broad group of non-coding small RNAs with important biological functions in germline cells. ![]()
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